Systemic Drug Therapy for Restenosis

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Prevention of restenosis by systemic drug therapy: back to the future?

In this issue of Circulation, 2 studies report a positive outcome in patients who received oral pharmacotherapy for the prevention of restenosis after stent placement. In the randomized, double-blind, placebo-controlled Cilostazol for Restenosis Trial (CREST) trial,1 patients were given cilostazol, a phosphodiesterase 3 inhibitor with antithrombotic2 and antiproliferative3 properties, for 6 mon...

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Gene Therapy for Restenosis.

a multifactorial problem consisting of cell proliferation, extracellular matr ix formation, thrombosis and chronic remodeling of the vessel wall. To prevent restenosis, vascular gene transfer strategies have been developed to limit cellular proliferation and intimal formation. Vascular gene transfer is the transfer of foreign or native genes into vascular cells to modulate gene expression. Earl...

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Drug-Eluting Stent Restenosis

OBJECTIVES We sought to determine if the angiographic pattern of in-stent restenosis in drug-eluting stents (DES) maintains its prognostic importance. BACKGROUND The pattern of restenosis in the bare-metal stent era had a significant impact on therapeutic outcomes. METHODS We identified a total of 250 consecutive restenotic lesions in 203 patients (66.4% sirolimuseluting stents and 33.6% paclit...

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ژورنال

عنوان ژورنال: Circulation

سال: 2002

ISSN: 0009-7322,1524-4539

DOI: 10.1161/01.cir.0000038412.38399.d5